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Available To Book Add Round-Trip Air from Lower 48 States for $495

Lower Mississippi River

Date: May 15-23, 2026
Starting Price: $5,995
Trip Length: 8 nights
Trip: New Orleans, Louisiana to Memphis, Tennessee
Cruise line: American Cruise Lines | American Serenade

Cruise the mighty Mississippi River from New Orleans to Memphis as you meander through stunning scenery and historical landscapes cruising 7 nights aboard American Cruise Lines’ American Serenade. Enjoy an included 1-night stay in New Orleans, where you can experience the soulful rhythms of jazz and the allure of the French Quarter, before embarking on a journey through the heart of America.

Immerse yourself in the serene beauty of the Mississippi River as you make way for Oak Valley. Stroll beneath the canopy of 300-year-old trees and explore well-preserved mansions while hearing stories of those who once lived here. Eat like a local in Louisiana’s state capital, Baton Rouge, as you dine on authentic Cajun and Creole cuisine. In Natchez, Mississippi’s oldest city, visit the famous Museum of African American History and Culture. The love for history and literature runs deep in Vicksburg. Experience the abundant museums and expand your imagination by learning about famous authors and poets from this port city. Continue along the Mississippi to your final destination, Memphis, where you can spend a day paying homage to Elvis, the King of Rock, at Graceland or explore the National Civil Rights Museum to deepen your understanding of America’s history.

Trip Map Larger Map

Features

MISSISSIPPI RIVER CRUISE INCLUDING:

  • INCLUDED 1-NIGHT HOTEL STAY
  • AWARD-WINNING SHORE EXCURSIONS
  • 100% OUTSIDE-FACING STATEROOMS
  • EXCLUSIVE ACCESS TO SMALL PORTS
  • ALL-INCLUSIVE FINE DINING
  • COMPLIMENTARY COCKTAIL HOURS
  • GRATUITIES, PORT CHARGES, AND FEES

Air Cities

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Itinerary

  • May 15: New Orleans, Louisiana - Hotel Stay
  • May 16: New Orleans Embarkation & Begin Cruising
  • May 17: Oak Alley, Louisiana
  • May 18: Baton Rouge, Louisiana
  • May 19: Natchez, Mississippi
  • May 20: Vicksburg, Mississippi
  • May 21: Cruising the Mississippi River
  • May 22: Memphis, Tennessee
  • May 23: Memphis, Tennessee

Deck Plans

Cancellation Policy

REFUNDS AND CANCELLATIONS: If you change your plans or cancel, your rights to a refund are limited. Submit a written cancellation to cancel@gonext.com. Upon receipt of a written cancellation from you, an American Cruise Lines non-refundable cancellation administrative fee of $250.00 per person will be applied to the following table.
Cruise Cancellation Fees:
91 days or more =full refund*
90-46 days =50% per person*
45 days or less =100% per person*
Any requests for cancellation must be communicated to Go Next in writing. Applicable refunds, if any, will be made within 14 days after the cancellation. (Subject to change; refer to your brochure for current rates.)
*All cancellations will incur an American Cruise Lines non-refundable $250 per person cancellation administrative charge.

Travel Insurance

Travel Insurance is more important than ever and we recommend it for your upcoming trip. Created with Go Next travelers in mind, our Travelex travel protection plan gives you and your loved ones options when unexpected situations affect your trip. Let us help you Dream. Explore. Travel On.

For more information on benefits, rates, and details – Click Here.

Available To Book

Lower Mississippi River

Date: May 15-23, 2026
Starting Price: $5,995
Trip Length: 8 nights
Trip: New Orleans, Louisiana to Memphis, Tennessee
Cruise line: American Cruise Lines | American Serenade
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